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Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor, has been shown to reduce the risk of CV death or heart failure hospitalization and improve symptoms among patients with chronic HFrEF compared to enalapril, the gold standard angiotensin-converting enzyme inhibitor. This paper reviews the current understanding of the effects of sacubitril/valsartan and highlights expected developments over the next 5 years, including potential new indications for use. Learn more in JACC: Heart Failure. Link in bio. - @americancollegeofcardiology on Instagram

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